河北省心腦血管病防治協(xié)同創(chuàng)新中心簡(jiǎn)介
Hebei Collaborative Innovation Center for Cardio-cerebral Vascular Disease
心腦血管病是造成國(guó)人死亡的第一原因，是危害人類(lèi)健康的主要疾病。“河北省心腦血管病防治協(xié)同創(chuàng)新中心”（以下簡(jiǎn)稱(chēng)“中心”）的建立始于2012年3月15日由教育部和財(cái)政部實(shí)施的“高等學(xué)校創(chuàng)新能力提升計(jì)劃”（即“2011計(jì)劃”）。“中心”以降低心腦血管病發(fā)病率、提高人民健康水平為目的，以創(chuàng)新能力提升為突破，在基礎(chǔ)科學(xué)研究之上，以協(xié)同創(chuàng)新、科研成果的快速臨床轉(zhuǎn)化為工作重點(diǎn)，積極開(kāi)展“原創(chuàng)性、前瞻性和應(yīng)用性”研究，努力為我省乃至國(guó)家的心腦血管病防治提供強(qiáng)有力的理論支撐，人才保障和智力支持。
“中心”由三個(gè)國(guó)家臨床重點(diǎn)專(zhuān)科建設(shè)項(xiàng)目——河北醫(yī)科大學(xué)第二醫(yī)院神經(jīng)內(nèi)科、心血管內(nèi)科和心臟大血管外科牽頭，聯(lián)合河北省神經(jīng)病學(xué)重點(diǎn)實(shí)驗(yàn)室、河北省心腦血管病研究所、山東第一醫(yī)科大學(xué)（原泰山醫(yī)學(xué)院）動(dòng)脈粥樣硬化研究所、河北醫(yī)科大學(xué)病理生理及生理教研室（河北省重點(diǎn)學(xué)科）、國(guó)家著名心腦血管病藥物研發(fā)企業(yè)——石藥集團(tuán)、河北省疾病預(yù)防控制中心、同時(shí)聯(lián)合省內(nèi)11個(gè)設(shè)區(qū)市三級(jí)甲等醫(yī)院的心腦血管病診療研究機(jī)構(gòu)和相關(guān)臨床科室，瞄準(zhǔn)國(guó)際前沿，服務(wù)地方，凝練4大協(xié)同創(chuàng)新方向：①心腦血管病關(guān)鍵病例機(jī)制研究與臨床治療策略探討；②創(chuàng)新心腦血管病治療模式，提高治愈率、降低殘疾率；③心腦血管病新藥研發(fā)與有效藥物篩選；④心腦血管病聯(lián)合防控體系建設(shè)。打造國(guó)內(nèi)一流、多學(xué)科合作、優(yōu)勢(shì)互補(bǔ)的綜合平臺(tái)，匯聚在國(guó)際學(xué)術(shù)界有重大影響力的著名專(zhuān)家學(xué)者為平臺(tái)負(fù)責(zé)人，領(lǐng)導(dǎo)核心團(tuán)隊(duì)開(kāi)展前沿性研究工作。
為了集中力量對(duì)血管疾病進(jìn)行系統(tǒng)攻關(guān)研究，2015年1月25日，基于河北省心腦血管病防治協(xié)同創(chuàng)新中心、河北醫(yī)科大學(xué)第二醫(yī)院及山東第一醫(yī)科大學(xué)動(dòng)脈粥樣硬化研究所而建立“河北省血管穩(wěn)態(tài)重點(diǎn)實(shí)驗(yàn)室”，并于2018年6月8日通過(guò)河北省科學(xué)技術(shù)廳組織的“省級(jí)重點(diǎn)實(shí)驗(yàn)室”驗(yàn)收，已納入省級(jí)重點(diǎn)實(shí)驗(yàn)室管理。實(shí)驗(yàn)室具備國(guó)際一流的神經(jīng)血管分析和動(dòng)態(tài)觀測(cè)平臺(tái)，配備高精尖儀器設(shè)備和頂級(jí)數(shù)據(jù)分析系統(tǒng)，并擁有臨床病房作為基地，開(kāi)展臨床應(yīng)用研究。
“中心”在建設(shè)中獲得了國(guó)家自然科學(xué)基金，河北省教育廳、財(cái)政廳、衛(wèi)健委（原衛(wèi)計(jì)委）、科技廳，河北醫(yī)科大學(xué)以及石藥集團(tuán)的大力支持。共建單位前期及成立后共榮獲國(guó)家科技進(jìn)步二等獎(jiǎng)3項(xiàng)，國(guó)家技術(shù)發(fā)明二等獎(jiǎng)1項(xiàng)，河北省科技進(jìn)步一等獎(jiǎng)8項(xiàng)，河北省科技進(jìn)步二等獎(jiǎng)11項(xiàng)，河北省科技進(jìn)步三等獎(jiǎng)35項(xiàng)，中國(guó)藥學(xué)會(huì)科學(xué)技術(shù)三等獎(jiǎng)1項(xiàng)。目前已發(fā)表學(xué)術(shù)論文2538篇，其中SCI論文324篇，其中8篇論文榮獲國(guó)家衛(wèi)計(jì)委腦防辦百篇優(yōu)秀論文。起草了《中國(guó)腦梗死中西醫(yī)結(jié)合診治指南2017》，參加撰寫(xiě)腦血管病指南6部，舉辦腦血管病新進(jìn)展學(xué)習(xí)班4期，在全國(guó)專(zhuān)業(yè)學(xué)術(shù)會(huì)議大會(huì)交流20次。建成了河北省腦血管病分級(jí)診療區(qū)域中心-石家莊市17個(gè)縣和24個(gè)社區(qū)醫(yī)院雙向轉(zhuǎn)診網(wǎng)絡(luò)，是“河北省腦血管病規(guī)范化治療培訓(xùn)基地”、“河北省疑難腦血管病遠(yuǎn)程會(huì)診中心”，極大地促進(jìn)了河北省腦血管病診療水平提升，團(tuán)隊(duì)獲得了“河北省高校李保國(guó)式科技服務(wù)團(tuán)隊(duì)”。
“中心”本著優(yōu)勢(shì)互補(bǔ)、資源共享、互惠互利的原則，歡迎國(guó)內(nèi)外醫(yī)療單位、專(zhuān)家學(xué)者積極參與“中心”的協(xié)同創(chuàng)新工作。
河北省心腦血管病防治協(xié)同創(chuàng)新中心的病房在17樓，醫(yī)辦室電話：0311-66636272，護(hù)理站電話：0311-66636271；重點(diǎn)實(shí)驗(yàn)室在18樓，聯(lián)系電話：0311-66636287。
地址：河北醫(yī)科大學(xué)第二醫(yī)院北院區(qū)，中華北大街309號(hào)
附：近2年SCI論文匯總
1. Cui F, Guan Y, Guo J, et al. Chronic intermittent hypobaric hypoxia protects vascular endothelium by ameliorating autophagy in metabolic syndrome rats[J]. Life Sciences, 2018, 205:145-154.
2. Yang Y, Zhang X J, Zhang C, et al. Loss of neuronal CD200 contributed to microglial activation after acute cerebral ischemia in mice[J]. Neuroscience Letters, 2018, 678:48-54.
3. Chen Y, Jin S, Teng X, et al. Hydrogen Sulfide Attenuates LPS-Induced Acute Kidney Injury by Inhibiting Inflammation and Oxidative Stress[J]. Oxidative Medicine & Cellular Longevity, 2018, 2018:6717212.
4. Yuan F, Wang H, Feng J, et al. Leptin Signaling in the Carotid Body Regulates a Hypoxic Ventilatory Response Through Altering TASK Channel Expression[J]. Frontiers in Physiology, 2018, 9:249.
5. Li G Q, Wang Z, Zhao T, et al. Role of cannabinoid receptor type 1 in rostral ventrolateral medulla in high-fat diet-induced hypertension in rats[J]. Journal of Hypertension, 2018, 36(4):1.
6. Feng P, Zhang X, Li D, et al. Two novel dual GLP-1/GIP receptor agonists are neuroprotective in the MPTP mouse model of Parkinson's disease[J]. Neuropharmacology, 2018, 133:385-394.
7. Congrui M F, Na L, Yujia M Y, et al. Chronic intermittent hypobaric hypoxia provides vascular protection in the aorta of the 2-kidney, 1-clip rat model of hypertension[J]. Canadian Journal of Physiology & Pharmacology, 2018, 96(8):807-814.
8. Chen Y, Zhang X, He J, et al. Delayed Administration of the Glucagon-Like Peptide 1 Analog Liraglutide Promoting Angiogenesis after Focal Cerebral Ischemia in Mice[J]. Journal of Stroke and Cerebrovascular Diseases, 2018, 27(5):1318-1325.
9. Qiu X, Liu K, Xiao L, Jin S, Dong J, Teng X, et al. Alpha-lipoic acid regulates the autophagy of vascular smooth muscle cells in diabetes by elevating hydrogen sulfide level[J]. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2018;1864(11):3723-3738.
10. Li L, Kang Y X, Ji X M, et al. Finasteride inhibited brain dopaminergic system and open-field behaviors in adolescent male rats[J]. CNS Neuroscience & Therapeutics, 2018, 24(2):115-125.
11. Hao W, Yang R, Yang Y, et al. Stellate ganglion block ameliorates vascular calcification by inhibiting endoplasmic reticulum stress[J]. Life Sciences, 2018, 193:1-8.
12. Xiao L, Dong J H, Teng X, et al. Hydrogen sulfide improves endothelial dysfunction in hypertension by activating peroxisome proliferator-activated receptor delta/endothelial nitric oxide synthase signaling[J]. Journal of Hypertension, 2018, 36(3):651.
13. Jin S, Tan B, Teng X, et al. Diurnal Fluctuations in Plasma Hydrogen Sulfide of the Mice[J]. Frontiers in Pharmacology, 2017, 8:682.
14. Jin S, Teng X, Xiao L, et al. Hydrogen sulfide ameliorated L-NAME-induced hypertensive heart disease by the Akt/eNOS/NO pathway[J]. Experimental Biology & Medicine, 2017, 242(18):1831-1841.
15. Li H, Teng X, Yang R, et al. Hydrogen Sulfide Facilitates the Impaired Sensitivity of Carotid Sinus Baroreflex in Rats with Vascular Calcification[J]. Frontiers in Pharmacology, 2017, 8:629.
16. Jing Y, Li Z, Wang H, et al. Protective Effects of Chronic Intermittent Hypobaric Hypoxia Pretreatment against Aplastic Anemia through Improving the Adhesiveness and Stress of Mesenchymal Stem Cells in Rats[J]. Stem Cells International,2017, 2017:5706193.
17. Jiao G, Zhang G, Wang H, et al. Glucose Intake Alters Expression of Neuropeptides Derived from Proopiomelanocortin in the Lateral Hypothalamus and the Nucleus Accumbens in Fructose Preference Rats[J]. Neural Plasticity, 2017, 2017(3):1-7.
18. Gao Y, Zhou JJ, Zhu Y, Wang L, Kosten TA, Zhang X, Li DP. Neuroadaptations of presynaptic and postsynaptic GABAB receptor function in the paraventricular nucleus in response to chronic unpredictable stress.Br J Pharmacol. 2017 Sep;174(17):2929-2940.
19. Chen R, Kong P, Zhang F, Shu YN, Nie X, Dong LH, Lin YL, Xie XL, Zhao LL, Zhang XJ, Han M. EZH2-mediated α-actin methylation needs lncRNA TUG1, and promotes the cortex cytoskeleton formation in VSMCs.Gene. 2017 Jun 15;616:52-57.
20. Fu C, Xue J, Wang R, Chen J, Ma L, Liu Y, Wang X, Guo F, Zhang Y, Zhang X, Wang S. Chemosensitive Phox2b-expressing neurons are crucial for hypercapnicventilatory response in the nucleus tractussolitarius.J Physiol. 2017 May 10.
21. Li X, Su L, Zhang X, Zhang C, Wang L, Li Y, Zhang Y, He T, Zhu X, Cui L. Ulinastatindownregulates TLR4 and NF-kB expression and protects mouse brains against ischemia/reperfusion injury.Neurol Res. 2017 Apr;39(4):367-373.
22. He W, Cui L, Zhang C, Zhang X, He J, Xie Y, Chen Y. Sonic hedgehog promotes neurite outgrowth of cortical neurons under oxidative stress: Involving of mitochondria and energy metabolism.Exp Cell Res. 2017 Jan 1;350(1):83-90.
23. Tian H, Yao ST, Yang NN, Ren J, Jiao P, Zhang X, Li DX, Zhang GA, Xia ZF, Qin SC. D4F alleviates macrophage-derived foam cell apoptosis by inhibiting the NF-κB-dependent Fas/FasL pathway. Sci Rep. 2017 Aug 4;7(1):7333.）
24. Li Y, Zhang X, Cui L, Chen R, Zhang Y, Zhang C, Zhu X, He T, Shen Z, Dong L, Zhao J, Wen Y, Zheng X, Li P. Salvianolic Acids Enhance Cerebral Angiogenesis and Neurological Recovery by Activating JAK2/STAT3 Signaling Pathway after Ischemic Stroke in Mice. J Neuro chem. 2017 Oct;143(1):87-99.
25. Miao J, Wang L, Zhang X, Zhu C, Cui L, Ji H, Liu Y, Wang X. Protective Effect of Aliskiren in Experimental Ischemic Stroke: Up-Regulated p-PI3K, p-AKT, Bcl-2 Expression, Attenuated Bax Expression. Neurochem Res. 2016 Sep;41(9):2300-10.
26. Ye Zhang a; Xiangjian Zhang; Lili Cui a; Rong Chen a; Cong Zhang a; Yaoru Li a; Tingting He a; Xingyuan Zhu a; Zuyuan Shen a; Lipeng Dong a; Jingru Zhao a; Ya Wen a; Xiufen Zheng a; Pan Li. Salvianolic Acids for Injection (SAFI) Promotes Functional Recovery and Neurogenesis via Sonic Hedgehog Pathway after Stroke in Mice. Neurochem Int. 2017 Nov;110:38-48.
27. Zhang L, Guo H, Yuan F, Hong ZC, Tian YM, Zhang XJ, Zhang Y. Limb remote ischemic per-conditioning protects heart against ischemia/reperfusion injury through opioid system in rats. Can J PhysiolPharmacol. 2017 Aug 1.
28. Li D, Liu C, Yang C, Wang D, Wu D, Qi Y, Su Q, Gao G, Xu Z, Guo Y. Slow intrathecal injection of rAAVrh10 enhances its transduction of spinal cord and therapeutic efficacy in a mutant SOD1 model of ALS. Neuroscience. 2017 Oct 9;365:192-205.
29. Zhang K, Yan J, Wang L, Tian X, Zhang T, Guo L, Li B, Wang W, Liu X. The Pyk2/MCU pathway in the rat middle cerebral artery occlusion model of ischemic stroke. Neurosci Res. 2017 Sep 12. pii: S0168-0102(17)30464-9.
30. Jia LJ, Qu ZZ, Zhang XQ, Tian YJ, Wang Y. Uremic encephalopathy with isolated brainstem involvement revealed by magnetic resonance image: a case report. BMC Neurol. 2017 Aug 8;17(1):154.
31. Hu M, Liu Z, Lv P, Wang H, Zhu Y, Qi Q, Xu J, Gao L. Nimodipine activates neuroprotective signaling events and inactivates autophages in the VCID rat hippocampus. Neurol Res. 2017 Oct;39(10):904-909.
32. Zhang C, Zhao S, Zang Y, Gu F, Mao S, Feng S, Hu L, Zhang C. The efficacy and safety of Dl-3n-butylphthalide on progressive cerebral infarction: A randomized controlled STROBE study. Medicine (Baltimore). 2017 Jul;96(30):e7257.
33. Hou H, Miao J, Cao R, Han M, Sun Y, Liu X, Guo L. Rapamycin Ameliorates Experimental Autoimmune Encephalomyelitis by Suppressing the mTOR-STAT3 Pathway. Neurochem Res. 2017 May 30.
34. Sun C, Liu Y, Liu Y, Zhao M, Zhai J, Hao P, Wang Y, Ji Y. Characterization of aromatase expression in the spinal cord of an animal model of familial ALS. Brain Res Bull. 2017 Jun;132:180-189.
35. Dong RF, Zhang B, Tai LW, Liu HM, Shi FK, Liu NN. The Neuroprotective Role of MiR-124-3p in a 6-Hydroxydopamine-Induced Cell Model of Parkinson's Disease via the Regulation of ANAX5. J Cell Biochem. 2017 May 25. doi: 10.1002/jcb.26170.
36. Ji YX, Zhao M, Liu YL, Chen LS, Hao PL, Sun C. Expression of aromatase and estrogen receptors in lumbar motoneurons of mice. NeurosciLett. 2017 Jul 13;653:7-11.
37. Xue Y, Qu Z, Fu J, Zhen J, Wang W, Cai Y, Wang W. The protective effect of astaxanthin on learning and memory deficits and oxidative stress in a mouse model of repeated cerebral ischemia/reperfusion. Brain Res Bull. 2017 May;131:221-228.
38. Wang L, Li B, Quan MY, Li L, Chen Y, Tan GJ, Zhang J, Liu XP, Guo L. Mechanism of oxidative stress p38MAPK-SGK1 signaling axis in experimental autoimmune encephalomyelitis (EAE). Oncotarget. 2017 Jun 27;8(26):42808-42816.
39. Yu P, Pan Y, Zheng H, Wang X, Yan H, Tong X, Jing J, Zhang X, Guo L, Wang Y. Association of high waist-to-height ratio with functional outcomes in patients with acute ischemic stroke: A report from the ACROSS-China study. Medicine (Baltimore). 2017 Mar;96(13):e6520.
40. Li Z, Duan W, Cui C, Liu Y, Li C, Liu Y. AAV9-IGF1 protects TDP-25 cells from apoptosis and oxidative stress partly via up-regulating the expression of VEGF in vitro. NeurosciLett. 2017 Feb 15;640:123-129.
41. Feng X, Hou H, Zou Y, Guo L. Defective autophagy is associated with neuronal injury in a mouse model of multiple sclerosis. Bosn J Basic Med Sci. 2017 May 20;17(2):95-103.
42. Wang W, Duan W, Wang Y, Wen D, Liu Y, Li Z, Hu H, Cui H, Cui C, Lin H, Li C. Intrathecal Delivery of ssAAV9-DAO Extends Survival in SOD1G93A ALS Mice. Neurochem Res. 2017 Apr;42(4):986-996.
43. Zhu Y, Bai L, Liang P, Kang S, Gao H, Yang H. Disrupted brain connectivity networks in acute ischemic stroke patients. Brain Imaging Behav. 2017 Apr;11(2):444-453.